Assay Detail
Binding
CHEMBL808906
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Binding affinity for sigma-2 receptor measured on rat liver membranes using [3H]DTG as radioligand in the presence of (+)-pentazocine
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.40 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51856 | — | — | 1 | 8.68 |
| CHEMBL53401 | — | — | 1 | 8.62 |
| CHEMBL53078 | — | — | 1 | 8.59 |
| CHEMBL423122 | — | — | 1 | 8.32 |
| CHEMBL54092 | — | — | 1 | 8.17 |
| CHEMBL298864 | — | — | 1 | 8.10 |
| CHEMBL54026 | — | — | 1 | 8.01 |
| CHEMBL53320 | — | — | 1 | 8.00 |
| CHEMBL54027 | — | — | 1 | 7.82 |
| CHEMBL54667 | — | — | 1 | 7.77 |
| CHEMBL298875 | — | — | 1 | 7.68 |
| CHEMBL51754 | — | — | 1 | 7.67 |
| CHEMBL54865 | — | — | 1 | 7.60 |
| CHEMBL53038 | — | — | 1 | 7.60 |
| CHEMBL53778 | — | — | 1 | 7.57 |
| CHEMBL416481 | — | — | 1 | 7.46 |
| CHEMBL50465 | — | — | 1 | 7.38 |
| CHEMBL301732 | — | — | 1 | 7.36 |
| CHEMBL54571 | — | — | 1 | 7.29 |
| CHEMBL50352 | — | — | 1 | 7.26 |
| CHEMBL52300 | — | — | 1 | 7.24 |
| CHEMBL52298 | — | — | 1 | 7.16 |
| CHEMBL50517 | — | — | 1 | 7.02 |
| CHEMBL416846 | — | — | 1 | 6.86 |
| CHEMBL53218 | — | — | 1 | 6.85 |
| CHEMBL52835 | — | — | 1 | 6.83 |
| CHEMBL298759 | — | — | 1 | 6.82 |
| CHEMBL53102 | — | — | 1 | 6.68 |
| CHEMBL53650 | — | — | 1 | 6.65 |
| CHEMBL52588 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51856 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL53401 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL53078 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL423122 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL54092 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL298864 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL54026 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL53320 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL54027 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL54667 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL298875 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL51754 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL54865 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL53038 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL53778 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL416481 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL50465 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL301732 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL54571 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL50352 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL52300 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL52298 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL50517 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL416846 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL53218 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL52835 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL298759 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL53102 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL53650 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL52588 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL54662 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL301302 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL301929 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL54866 | — | Ki | = | 419.0 | nM | 6.38 |