Assay Detail
Binding
CHEMBL808907
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Binding affinity for sigma-2 receptor measured on rat liver membranes using [3H]DTG as radioligand in the presence of (+)-pentazocine
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.62 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.77 |
| CHEMBL51959 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL51959 | — | Ki | = | 35.0 | nM | 7.46 |