Assay Detail
Binding
CHEMBL808909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Sigma 2 binding assay was done rat liver membrane, by labeling the binding site with [3H]DTG (DuPont-NEN) in the presence of [3H](+)-pentazocine (100 nM)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.43 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341139 | — | — | 1 | 8.48 |
| CHEMBL340185 | — | — | 1 | 8.06 |
| CHEMBL338140 | — | — | 1 | 7.64 |
| CHEMBL315146 | — | — | 1 | 7.52 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.47 |
| CHEMBL87414 | — | — | 1 | 7.17 |
| CHEMBL126257 | — | — | 1 | 7.00 |
| CHEMBL340815 | — | — | 1 | 6.86 |
| CHEMBL314170 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341139 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL340185 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL338140 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL315146 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL20730 | VESAMICOL | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL87414 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL126257 | — | Ki | = | 99.2 | nM | 7.00 |
| CHEMBL340815 | — | Ki | = | 139.2 | nM | 6.86 |
| CHEMBL314170 | — | Ki | = | 224.0 | nM | 6.65 |