Assay Detail
Binding
CHEMBL808910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Sigma 2 binding assay was done rat liver membrane, by labeling the binding site with [3H]-DTG (DuPont-NEN) in the presence of [3H](+)-pentazocine (100 nM)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339863 | — | — | 1 | 8.30 |
| CHEMBL337929 | — | — | 1 | 8.11 |
| CHEMBL127365 | — | — | 1 | 8.01 |
| CHEMBL339281 | — | — | 1 | 7.95 |
| CHEMBL126019 | — | — | 1 | 7.90 |
| CHEMBL340816 | — | — | 1 | 7.81 |
| CHEMBL338469 | — | — | 1 | 7.80 |
| CHEMBL127013 | — | — | 1 | 7.73 |
| CHEMBL126742 | — | — | 1 | 7.49 |
| CHEMBL405524 | — | — | 1 | 7.22 |
| CHEMBL339712 | — | — | 1 | 7.13 |
| CHEMBL338411 | — | — | 1 | 6.93 |
| CHEMBL125795 | — | — | 1 | 6.76 |
| CHEMBL127790 | — | — | 1 | 6.58 |
| CHEMBL126762 | — | — | 1 | 6.56 |
| CHEMBL127180 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339863 | — | Ki | = | 4.95 | nM | 8.30 |
| CHEMBL337929 | — | Ki | = | 7.71 | nM | 8.11 |
| CHEMBL127365 | — | Ki | = | 9.87 | nM | 8.01 |
| CHEMBL339281 | — | Ki | = | 11.28 | nM | 7.95 |
| CHEMBL126019 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL340816 | — | Ki | = | 15.36 | nM | 7.81 |
| CHEMBL338469 | — | Ki | = | 15.87 | nM | 7.80 |
| CHEMBL127013 | — | Ki | = | 18.8 | nM | 7.73 |
| CHEMBL126742 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL405524 | — | Ki | = | 60.8 | nM | 7.22 |
| CHEMBL339712 | — | Ki | = | 73.33 | nM | 7.13 |
| CHEMBL338411 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL125795 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL127790 | — | Ki | = | 260.1 | nM | 6.58 |
| CHEMBL126762 | — | Ki | = | 275.1 | nM | 6.56 |
| CHEMBL127180 | — | Ki | = | 357.3 | nM | 6.45 |