Assay Detail
Binding
CHEMBL808967
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In vitro inhibition of rat squalene synthase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The squalestatins: Potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.97 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57066 | — | — | 1 | 8.15 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | — | 1 | 7.92 |
| CHEMBL30572 | — | — | 1 | 7.82 |
| CHEMBL412861 | — | — | 1 | 7.68 |
| CHEMBL292586 | — | — | 1 | 7.66 |
| CHEMBL294227 | — | — | 1 | 7.64 |
| CHEMBL293562 | — | — | 1 | 7.36 |
| CHEMBL58760 | — | — | 1 | 7.10 |
| CHEMBL292169 | — | — | 1 | 6.92 |
| CHEMBL57067 | — | — | 1 | 6.87 |
| CHEMBL58161 | — | — | 1 | 6.85 |
| CHEMBL58260 | — | — | 1 | 6.66 |
| CHEMBL56545 | — | — | 1 | 6.61 |
| CHEMBL282341 | — | — | 1 | 6.40 |
| CHEMBL301051 | — | — | 1 | 6.13 |
| CHEMBL58761 | — | — | 1 | 6.10 |
| CHEMBL294147 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57066 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL30572 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL412861 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL292586 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL294227 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL293562 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL58760 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL292169 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL57067 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL58161 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL58260 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL56545 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL282341 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL301051 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL58761 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL294147 | — | IC50 | = | 25000.0 | nM | 4.60 |