Assay Detail
Binding
CHEMBL808968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against squalene synthase from male rat liver microsomes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structurally simplified squalestatins: monocyclic 1,3-dioxane analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.36 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418767 | — | — | 1 | 8.22 |
| CHEMBL160176 | — | — | 1 | 7.96 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | — | 1 | 7.92 |
| CHEMBL89566 | — | — | 1 | 7.82 |
| CHEMBL157542 | — | — | 1 | 7.41 |
| CHEMBL368664 | — | — | 1 | 7.24 |
| CHEMBL158930 | — | — | 1 | 6.70 |
| CHEMBL158525 | — | — | 1 | 6.57 |
| CHEMBL89073 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418767 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL160176 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL89566 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL157542 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL368664 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL158930 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL158525 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL89073 | — | IC50 | = | 380.0 | nM | 6.42 |