Assay Detail
Binding
CHEMBL808970
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Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]FPP as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.83 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87292 | — | — | 1 | 9.15 |
| CHEMBL348349 | — | — | 1 | 9.00 |
| CHEMBL158707 | — | — | 1 | 8.24 |
| CHEMBL158517 | — | — | 1 | 7.89 |
| CHEMBL160240 | — | — | 1 | 7.82 |
| CHEMBL160267 | — | — | 1 | 7.77 |
| CHEMBL160318 | — | — | 1 | 7.75 |
| CHEMBL158448 | — | — | 1 | 7.72 |
| CHEMBL158862 | — | — | 1 | 7.46 |
| CHEMBL158851 | — | — | 1 | 7.46 |
| CHEMBL158978 | — | — | 1 | 7.12 |
| CHEMBL351866 | — | — | 1 | 6.84 |
| CHEMBL351151 | — | — | 1 | 6.77 |
| CHEMBL158844 | — | — | 1 | 6.72 |
| CHEMBL158527 | — | — | 1 | 6.70 |
| CHEMBL346762 | — | — | 1 | 6.57 |
| CHEMBL159021 | — | — | 1 | 6.54 |
| CHEMBL158154 | — | — | 1 | 6.13 |
| CHEMBL347175 | — | — | 1 | 5.70 |
| CHEMBL160796 | — | — | 1 | 5.70 |
| CHEMBL160284 | — | — | 1 | 5.34 |
| CHEMBL158931 | — | — | 1 | 5.21 |
| CHEMBL158667 | — | — | 1 | 5.16 |
| CHEMBL347856 | — | — | 1 | 5.09 |
| CHEMBL160340 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87292 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL348349 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL158707 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL158517 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL160240 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL160267 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL160318 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL158448 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL158862 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL158851 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL158978 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL351866 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL351151 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL158844 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL158527 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL346762 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL159021 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL158154 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL347175 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL160796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL160284 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL158931 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL158667 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL347856 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL160340 | — | IC50 | = | 14200.0 | nM | 4.85 |