Assay Detail
Binding
CHEMBL808971
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In vitro inhibition against rat microsomal squalene synthase (SS)
43
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317462 | — | — | 1 | 8.52 |
| CHEMBL327957 | — | — | 1 | 8.40 |
| CHEMBL322868 | — | — | 1 | 8.30 |
| CHEMBL100506 | — | — | 1 | 8.22 |
| CHEMBL322662 | — | — | 1 | 8.15 |
| CHEMBL279261 | — | — | 3 | 8.15 |
| CHEMBL319172 | — | — | 1 | 8.10 |
| CHEMBL319077 | — | — | 1 | 7.96 |
| CHEMBL101492 | — | — | 1 | 7.89 |
| CHEMBL100727 | — | — | 1 | 7.75 |
| CHEMBL100392 | — | — | 1 | 7.75 |
| CHEMBL99626 | — | — | 1 | 7.68 |
| CHEMBL99679 | — | — | 1 | 7.57 |
| CHEMBL316713 | — | — | 1 | 7.52 |
| CHEMBL99839 | — | — | 1 | 7.52 |
| CHEMBL329766 | — | — | 1 | 7.40 |
| CHEMBL327738 | — | — | 1 | 7.22 |
| CHEMBL319389 | — | — | 1 | 7.22 |
| CHEMBL419899 | — | — | 1 | 7.22 |
| CHEMBL100912 | — | — | 1 | 7.16 |
| CHEMBL100913 | — | — | 1 | 6.88 |
| CHEMBL329516 | — | — | 1 | 6.85 |
| CHEMBL100691 | — | — | 1 | 6.79 |
| CHEMBL317316 | — | — | 1 | 6.72 |
| CHEMBL100180 | — | — | 1 | 6.70 |
| CHEMBL316840 | — | — | 1 | 6.62 |
| CHEMBL322664 | — | — | 1 | 6.57 |
| CHEMBL329513 | — | — | 1 | 6.43 |
| CHEMBL318301 | — | — | 1 | 6.24 |
| CHEMBL319594 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317462 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL327957 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL322868 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL100506 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279261 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL322662 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL319172 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL319077 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL101492 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL279261 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL100727 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL100392 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL99626 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL99679 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL316713 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99839 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL329766 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL327738 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL319389 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL419899 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL100912 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL279261 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL100913 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL329516 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL100691 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL317316 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL100180 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL316840 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL322664 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL329513 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL318301 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL319594 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL101863 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL101863 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL55300 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL102110 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL101283 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL102958 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL100396 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL102188 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL98414 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL97873 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL103895 | — | IC50 | > | 2500.0 | nM | - |