Assay Detail
Binding
CHEMBL808974
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Inhibition of rat liver squalene synthase(SQS)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Semi-synthetic qualestatins: Squalene synthase inhibition and antifungal activity. The SAR of C6 and C7 modifications
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314078 | — | — | 1 | 8.70 |
| CHEMBL263760 | — | — | 1 | 8.52 |
| CHEMBL315781 | — | — | 1 | 8.52 |
| CHEMBL330511 | — | — | 1 | 8.40 |
| CHEMBL315705 | — | — | 1 | 8.40 |
| CHEMBL418767 | — | — | 1 | 8.22 |
| CHEMBL263277 | — | — | 1 | 8.22 |
| CHEMBL88601 | — | — | 1 | 8.15 |
| CHEMBL330577 | — | — | 1 | 8.10 |
| CHEMBL436691 | — | — | 1 | 8.10 |
| CHEMBL328960 | — | — | 1 | 8.10 |
| CHEMBL315074 | — | — | 1 | 8.05 |
| CHEMBL314850 | — | — | 1 | 8.00 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | — | 1 | 7.92 |
| CHEMBL89566 | — | — | 1 | 7.82 |
| CHEMBL313884 | — | — | 1 | 7.77 |
| CHEMBL89470 | — | — | 1 | 7.25 |
| CHEMBL316436 | — | — | 1 | 7.23 |
| CHEMBL432033 | — | — | 1 | 6.55 |
| CHEMBL87072 | — | — | 1 | 6.52 |
| CHEMBL89073 | — | — | 1 | 6.42 |
| CHEMBL87902 | — | — | 1 | - |
| CHEMBL313675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314078 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL263760 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL315781 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL330511 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL315705 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL418767 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL263277 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL88601 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL330577 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL436691 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL328960 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL315074 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL314850 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL89566 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL313884 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL89470 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL316436 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL432033 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL87072 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL89073 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL87902 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL313675 | — | IC50 | > | 500.0 | nM | - |