Assay Detail
Binding
CHEMBL809096
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Compound was tested for inhibition of TEM-1, class A of beta-lactamases.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.98 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123481 | — | — | 1 | 5.44 |
| CHEMBL332565 | — | — | 1 | 4.89 |
| CHEMBL122209 | — | — | 1 | 4.85 |
| CHEMBL121924 | — | — | 1 | 4.72 |
| CHEMBL333330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123481 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL332565 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL122209 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL121924 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL333330 | — | IC50 | 8500.0 | nM | - |