Assay Detail
Binding
CHEMBL809097
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Inhibitory activity against class A TEM-1 beta-lactamase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.31 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297805 | — | — | 1 | 8.12 |
| CHEMBL44932 | — | — | 1 | 8.08 |
| CHEMBL295322 | — | — | 1 | 8.03 |
| CHEMBL42528 | — | — | 1 | 7.92 |
| CHEMBL416447 | — | — | 1 | 7.28 |
| CHEMBL47198 | — | — | 1 | 7.15 |
| CHEMBL44813 | — | — | 1 | 7.11 |
| CHEMBL44278 | — | — | 1 | 6.96 |
| CHEMBL43955 | — | — | 1 | 6.62 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 6.60 |
| CHEMBL289979 | — | — | 1 | 6.58 |
| CHEMBL44754 | — | — | 1 | 6.41 |
| CHEMBL45136 | — | — | 1 | 6.10 |
| CHEMBL297671 | — | — | 1 | 5.97 |
| CHEMBL45084 | — | — | 1 | 5.89 |
| CHEMBL290072 | — | — | 1 | 5.85 |
| CHEMBL44274 | — | — | 1 | 5.80 |
| CHEMBL46478 | — | — | 1 | 5.74 |
| CHEMBL295625 | — | — | 1 | 5.74 |
| CHEMBL45273 | — | — | 1 | 5.45 |
| CHEMBL44588 | — | — | 1 | 5.38 |
| CHEMBL297253 | — | — | 1 | 5.37 |
| CHEMBL415918 | — | — | 1 | 5.11 |
| CHEMBL296738 | — | — | 1 | 5.04 |
| CHEMBL46958 | — | — | 1 | 4.98 |
| CHEMBL289526 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297805 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL44932 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL295322 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL42528 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL416447 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL47198 | — | IC50 | = | 70.1 | nM | 7.15 |
| CHEMBL44813 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL44278 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL43955 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL289979 | — | IC50 | = | 261.5 | nM | 6.58 |
| CHEMBL44754 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL45136 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL297671 | — | IC50 | = | 1065.0 | nM | 5.97 |
| CHEMBL45084 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL290072 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL44274 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL46478 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL295625 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL45273 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL44588 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL297253 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL415918 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL296738 | — | IC50 | = | 9140.0 | nM | 5.04 |
| CHEMBL46958 | — | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL289526 | — | IC50 | = | 18520.0 | nM | 4.73 |