Assay Detail
Binding
CHEMBL809159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against sialidase (Flu B, 4 nM).
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.38 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50254 | — | — | 1 | 4.64 |
| CHEMBL54149 | — | — | 1 | 4.36 |
| CHEMBL51451 | — | — | 1 | 4.30 |
| CHEMBL100677 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50254 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL54149 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL51451 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL100677 | — | IC50 | = | 61000.0 | nM | 4.21 |