Assay Detail
Binding
CHEMBL809166
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Inhibition of influenza A virus sialidase activity
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352318 | — | — | 1 | 8.70 |
| CHEMBL167253 | — | — | 1 | 8.52 |
| CHEMBL354583 | — | — | 1 | 8.30 |
| CHEMBL349658 | — | — | 1 | 8.10 |
| CHEMBL354491 | — | — | 1 | 8.10 |
| CHEMBL353683 | — | — | 1 | 8.05 |
| CHEMBL164582 | — | — | 1 | 7.92 |
| CHEMBL424528 | — | — | 1 | 7.92 |
| CHEMBL165651 | — | — | 1 | 7.85 |
| CHEMBL442774 | — | — | 1 | 7.34 |
| CHEMBL436250 | — | — | 1 | 6.96 |
| CHEMBL167936 | — | — | 1 | 6.57 |
| CHEMBL164976 | — | — | 1 | 6.51 |
| CHEMBL167076 | — | — | 1 | 5.54 |
| CHEMBL164493 | — | — | 1 | 5.52 |
| CHEMBL166561 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352318 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL167253 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL354583 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL349658 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL354491 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL353683 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL164582 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL424528 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL165651 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL442774 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL436250 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL167936 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL164976 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL167076 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL164493 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL166561 | — | IC50 | = | 47000.0 | nM | 4.33 |