Assay Detail
Binding
CHEMBL809167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at Sigma opioid receptor type 1 on guinea pig brain membranes by [3H]pentazocine displacement.
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover sigma(1) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.14 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540331 | — | — | 2 | 9.30 |
| CHEMBL541091 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540331 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL540331 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL541091 | — | IC50 | = | 34.0 | nM | 7.47 |