Assay Detail
Binding
CHEMBL809254
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Ability to inhibit thymidylate synthase derived from human leukemia K562 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | K562 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues as inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389051 | — | — | 1 | 7.43 |
| CHEMBL347223 | — | — | 1 | 6.54 |
| CHEMBL348979 | — | — | 1 | 5.90 |
| CHEMBL161457 | — | — | 1 | 5.62 |
| CHEMBL158790 | — | — | 1 | 5.60 |
| CHEMBL22973 | — | — | 1 | 5.57 |
| CHEMBL350921 | — | — | 1 | 5.26 |
| CHEMBL161265 | — | — | 1 | 4.26 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389051 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL347223 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL348979 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL161457 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL158790 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL22973 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL350921 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL161265 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1622 | FOLIC ACID | IC50 | = | 290000.0 | nM | - |