Assay Detail
Binding
CHEMBL809260
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human thymidylate synthase (TS)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.14 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160054 | — | — | 1 | 7.17 |
| CHEMBL39175 | — | — | 1 | 4.26 |
| CHEMBL294973 | — | — | 1 | 4.00 |
| CHEMBL38902 | — | — | 1 | - |
| CHEMBL40850 | — | — | 1 | - |
| CHEMBL417696 | — | — | 1 | - |
| CHEMBL41459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160054 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL39175 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL294973 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL38902 | — | IC50 | = | 4200000.0 | nM | - |
| CHEMBL40850 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL417696 | — | IC50 | = | 2100000.0 | nM | - |
| CHEMBL41459 | — | IC50 | > | 5000000.0 | nM | - |