Assay Detail
Binding
CHEMBL809500
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Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | — | 1 | 7.01 |
| CHEMBL47146 | — | — | 1 | 5.66 |
| CHEMBL45340 | — | — | 1 | 5.52 |
| CHEMBL296014 | — | — | 1 | - |
| CHEMBL444832 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL47146 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL45340 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL296014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL444832 | — | IC50 | > | 10000.0 | nM | - |