Assay Detail
Binding
CHEMBL809502
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Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IM-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Aryl-1-azabicyclo[2.2.2]octanes as novel nonpeptide substance P antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.02 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 8.70 |
| CHEMBL122580 | — | — | 1 | 8.04 |
| CHEMBL166610 | — | — | 1 | 7.70 |
| CHEMBL2115528 | — | — | 1 | 7.41 |
| CHEMBL166816 | — | — | 1 | 6.85 |
| CHEMBL354564 | — | — | 1 | 6.80 |
| CHEMBL332140 | — | — | 1 | 6.64 |
| CHEMBL167066 | — | — | 1 | 6.62 |
| CHEMBL352697 | — | — | 1 | 6.46 |
| CHEMBL353416 | — | — | 1 | 6.16 |
| CHEMBL119947 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL122580 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL166610 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2115528 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL166816 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL354564 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL332140 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL167066 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL352697 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL353416 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL119947 | — | IC50 | = | 1400.0 | nM | 5.85 |