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Assay Detail

CHEMBL809520

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity of compound was measured towards Sigma receptor type 2 by using [3H]ditolylguanidine as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 3 — Cell-line / Tissue
Curated By Expert

Publication

Thioxanthene-derived analogs as sigma(1) receptor ligands.
Glennon RA, Ismaiel AM, Ablordeppey S, El-Ashmawy M, Fisher JB.
Bioorg Med Chem Lett (2004) 14 : 2217 -2220
PubMed 15081012 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.91 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302087 1 7.77
CHEMBL67808 1 7.60
CHEMBL305218 1 7.58
CHEMBL71883 1 7.55
CHEMBL72045 1 7.55
CHEMBL69256 1 7.50
CHEMBL71155 1 7.39
CHEMBL305461 1 7.29
CHEMBL303263 1 7.00
CHEMBL304283 1 6.85
CHEMBL71773 1 6.10
CHEMBL71616 1 6.05
CHEMBL282567 PROADIFEN 2.0 1 5.96
CHEMBL68905 1 5.89
CHEMBL72061 1 5.59
CHEMBL70352 BENACTYZINE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302087 Ki = 17.0 nM 7.77
CHEMBL67808 Ki = 25.0 nM 7.60
CHEMBL305218 Ki = 26.0 nM 7.58
CHEMBL71883 Ki = 28.0 nM 7.55
CHEMBL72045 Ki = 28.0 nM 7.55
CHEMBL69256 Ki = 32.0 nM 7.50
CHEMBL71155 Ki = 41.0 nM 7.39
CHEMBL305461 Ki = 51.0 nM 7.29
CHEMBL303263 Ki = 100.0 nM 7.00
CHEMBL304283 Ki = 142.0 nM 6.85
CHEMBL71773 Ki = 800.0 nM 6.10
CHEMBL71616 Ki = 900.0 nM 6.05
CHEMBL282567 PROADIFEN Ki = 1100.0 nM 5.96
CHEMBL68905 Ki = 1300.0 nM 5.89
CHEMBL72061 Ki = 2540.0 nM 5.59
CHEMBL70352 BENACTYZINE Ki - nM -