Assay Detail
Binding
CHEMBL809527
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Binding affinity against Sigma receptor type 2 was determined by the displacement of [3H]DTG/dextrallorphan radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.98 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313179 | — | — | 1 | 7.73 |
| CHEMBL87841 | — | — | 1 | 7.11 |
| CHEMBL84971 | — | — | 1 | 6.67 |
| CHEMBL315166 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313179 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL87841 | — | Ki | = | 78.1 | nM | 7.11 |
| CHEMBL84971 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL315166 | — | Ki | = | 385.0 | nM | 6.42 |