Assay Detail
Binding
CHEMBL809543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition against human Steroid 5-alpha-reductase type 2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.91 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25448 | — | — | 1 | 6.81 |
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25448 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 10000.0 | nM | 5.00 |