Assay Detail
Binding
CHEMBL809545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosterone
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 8.52 |
| CHEMBL135993 | — | — | 1 | 6.52 |
| CHEMBL136097 | — | — | 1 | 6.37 |
| CHEMBL2112735 | — | — | 1 | 6.37 |
| CHEMBL137040 | — | — | 1 | 6.33 |
| CHEMBL135651 | — | — | 2 | 6.24 |
| CHEMBL344363 | — | — | 1 | 5.50 |
| CHEMBL135351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL135993 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL136097 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2112735 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL137040 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL135651 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL135651 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL344363 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL135351 | — | IC50 | > | 10000.0 | nM | - |