Assay Detail
Binding
CHEMBL810000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of type 2 steroid-5-alpha-reductase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.47 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 9.22 |
| CHEMBL125209 | — | — | 1 | 8.27 |
| CHEMBL128023 | — | — | 1 | 6.90 |
| CHEMBL421627 | — | — | 1 | 6.83 |
| CHEMBL25448 | — | — | 1 | 6.81 |
| CHEMBL340027 | — | — | 1 | 6.66 |
| CHEMBL340181 | — | — | 1 | 6.66 |
| CHEMBL340684 | — | — | 1 | 6.55 |
| CHEMBL340715 | — | — | 1 | 6.55 |
| CHEMBL126686 | — | — | 1 | 6.53 |
| CHEMBL127702 | — | — | 1 | 6.48 |
| CHEMBL339912 | — | — | 1 | 6.37 |
| CHEMBL124803 | — | — | 1 | 6.35 |
| CHEMBL126968 | — | — | 1 | 6.24 |
| CHEMBL124750 | — | — | 1 | 6.15 |
| CHEMBL338376 | — | — | 1 | 6.07 |
| CHEMBL332781 | — | — | 1 | 5.98 |
| CHEMBL414427 | — | — | 1 | 5.96 |
| CHEMBL127760 | — | — | 1 | 5.89 |
| CHEMBL414428 | — | — | 1 | 5.87 |
| CHEMBL340305 | — | — | 1 | 5.86 |
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 5.76 |
| CHEMBL125260 | — | — | 1 | 5.67 |
| CHEMBL125579 | — | — | 1 | 5.66 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | - |
| CHEMBL323996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL125209 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL128023 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL421627 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL25448 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL340027 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL340181 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL340684 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL340715 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL126686 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL127702 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL339912 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL124803 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL126968 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL124750 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL338376 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL332781 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL414427 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL127760 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL414428 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL340305 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL125260 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL125579 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL710 | FINASTERIDE | IC50 | < | 0.1 | nM | - |
| CHEMBL323996 | — | IC50 | < | 0.1 | nM | - |