Assay Detail
Binding
CHEMBL810001
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In vitro inhibitory activity against human type 2 5-alpha reductase
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 8.57 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80160 | — | — | 1 | 10.00 |
| CHEMBL412425 | — | — | 1 | 9.92 |
| CHEMBL306722 | — | — | 1 | 9.80 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 9.74 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 9.74 |
| CHEMBL306554 | — | — | 1 | 9.70 |
| CHEMBL2298601 | — | — | 1 | 9.64 |
| CHEMBL312531 | — | — | 1 | 9.64 |
| CHEMBL311577 | — | — | 1 | 9.52 |
| CHEMBL308107 | — | — | 1 | 9.52 |
| CHEMBL77328 | — | — | 1 | 9.40 |
| CHEMBL307398 | — | — | 1 | 9.40 |
| CHEMBL311045 | — | — | 1 | 9.40 |
| CHEMBL77124 | — | — | 1 | 9.30 |
| CHEMBL77129 | — | — | 1 | 9.30 |
| CHEMBL78064 | — | — | 1 | 9.22 |
| CHEMBL76192 | — | — | 1 | 9.06 |
| CHEMBL73816 | — | — | 1 | 8.89 |
| CHEMBL309585 | — | — | 1 | 8.89 |
| CHEMBL78275 | — | — | 1 | 8.85 |
| CHEMBL76648 | — | — | 1 | 8.82 |
| CHEMBL76260 | — | — | 1 | 8.77 |
| CHEMBL312143 | — | — | 1 | 8.77 |
| CHEMBL3706586 | — | — | 1 | 8.74 |
| CHEMBL76693 | — | — | 1 | 8.74 |
| CHEMBL432729 | — | — | 1 | 8.72 |
| CHEMBL307181 | — | — | 1 | 8.68 |
| CHEMBL76892 | — | — | 1 | 8.64 |
| CHEMBL307626 | — | — | 1 | 8.62 |
| CHEMBL297524 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80160 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL412425 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL306722 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL306554 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2298601 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL312531 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL311577 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL308107 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL77328 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL307398 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL311045 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL77129 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL77124 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL78064 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL76192 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL73816 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL309585 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL78275 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL76648 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL76260 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL312143 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3706586 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL76693 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL432729 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL307181 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL76892 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL307626 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL297524 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL75982 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL308532 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3706583 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL78161 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL77765 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL80163 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL311874 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL77144 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL76536 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL80669 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL309261 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL76803 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL306507 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL24291 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3706585 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL75320 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL421696 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL77378 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL310710 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL76671 | — | IC50 | = | 40.0 | nM | 7.40 |