Assay Detail
Binding
CHEMBL810023
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Binding potency against SP receptor in bovine caudate using [3H]- as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Preparation and radiolabelling of CP-96,345, the first non-peptide substance P antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.54 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 8.42 |
| CHEMBL282331 | — | — | 1 | 7.25 |
| CHEMBL431690 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL282331 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL431690 | — | IC50 | = | 110.0 | nM | 6.96 |