Assay Detail
Binding
CHEMBL810049
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Inhibitory activity against Herpes simplex virus type-I specific thymidine kinase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Herpes simplex virus (type 1 / strain SC16) |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.95 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143935 | — | — | 1 | 6.52 |
| CHEMBL35886 | — | — | 1 | 5.52 |
| CHEMBL3143943 | — | — | 1 | 5.52 |
| CHEMBL16026 | — | — | 1 | 5.16 |
| CHEMBL287727 | — | — | 1 | 5.10 |
| CHEMBL15985 | — | — | 1 | 4.82 |
| CHEMBL2115349 | — | — | 1 | 4.60 |
| CHEMBL603175 | — | — | 1 | 4.52 |
| CHEMBL16193 | — | — | 1 | 4.30 |
| CHEMBL36877 | — | — | 1 | 4.30 |
| CHEMBL2092762 | — | — | 1 | 4.12 |
| CHEMBL3143941 | — | — | 1 | - |
| CHEMBL16185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143935 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL35886 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3143943 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL16026 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL287727 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL15985 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2115349 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL603175 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL16193 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL36877 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2092762 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3143941 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL16185 | — | EC50 | = | 140000.0 | nM | - |