Assay Detail
Binding
CHEMBL810063
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Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Thyrotropin-releasing hormone receptor (CHEMBL2467) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Conformationally restricted TRH analogs: a probe for the pyroglutamate region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.03 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39363 | — | — | 1 | 8.92 |
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | 8.00 |
| CHEMBL36631 | — | — | 1 | 5.82 |
| CHEMBL607173 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39363 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1472 | PROTIRELIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL36631 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL607173 | — | Ki | = | 4400.0 | nM | 5.36 |