Assay Detail
Binding
CHEMBL810077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pure human thymidylate synthase from extract of Manca human lymphoma cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Manca |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.61 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 8.00 |
| CHEMBL25889 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL25889 | — | IC50 | = | 60.0 | nM | 7.22 |