Assay Detail
Binding
CHEMBL810256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Steroid 5-alpha-reductase type I in human scalp homogenates
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Scalp |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.81 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 8.64 |
| CHEMBL118446 | — | — | 1 | 7.39 |
| CHEMBL118319 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL118446 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL118319 | — | IC50 | = | 41.0 | nM | 7.39 |