Assay Detail
Functional
CHEMBL810450
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Tested for the inhibitory activity against HIV-1 in Sup T1 cell lines assessed by syncytium formation and reverse transcriptase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUP-T1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design of irreversible, pseudo-C2-symmetric hiv-1 protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.70 |
| CHEMBL55197 | — | — | 1 | 7.52 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL55197 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 50.0 | nM | 7.30 |