Assay Detail
Binding
CHEMBL810667
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Compound was tested for its inhibitory activity against B/Victoria/102/85 (N2) sialidases.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.70 |
| CHEMBL317645 | — | — | 1 | 6.14 |
| CHEMBL295490 | — | — | 1 | 5.70 |
| CHEMBL300461 | — | — | 1 | 5.36 |
| CHEMBL419710 | — | — | 1 | - |
| CHEMBL73669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL317645 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL295490 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL300461 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL419710 | — | IC50 | > | 560000.0 | nM | - |
| CHEMBL73669 | — | IC50 | - | — | - |