Assay Detail
Binding
CHEMBL810670
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Inhibition of influenza B virus sialidase activity
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.19 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98906 | — | — | 1 | 5.82 |
| CHEMBL167805 | — | — | 1 | 5.72 |
| CHEMBL167253 | — | — | 1 | 5.64 |
| CHEMBL354583 | — | — | 1 | 5.50 |
| CHEMBL349658 | — | — | 1 | 5.48 |
| CHEMBL352318 | — | — | 1 | 5.35 |
| CHEMBL436250 | — | — | 1 | 5.33 |
| CHEMBL167936 | — | — | 1 | 5.28 |
| CHEMBL424528 | — | — | 1 | 5.21 |
| CHEMBL354491 | — | — | 1 | 5.10 |
| CHEMBL353683 | — | — | 1 | 4.92 |
| CHEMBL354666 | — | — | 1 | 4.80 |
| CHEMBL442774 | — | — | 1 | 4.44 |
| CHEMBL164582 | — | — | 1 | 4.00 |
| CHEMBL166561 | — | — | 1 | - |
| CHEMBL165651 | — | — | 1 | - |
| CHEMBL164493 | — | — | 1 | - |
| CHEMBL164976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98906 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL167805 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL167253 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL354583 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL349658 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL352318 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL436250 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL167936 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL424528 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL354491 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL353683 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL354666 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL442774 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL164582 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL166561 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL165651 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL164493 | — | IC50 | > | 360000.0 | nM | - |
| CHEMBL164976 | — | IC50 | = | 210000.0 | nM | - |