Assay Detail
Binding
CHEMBL810673
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Inhibition of influenza B virus sialidase activity
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.29 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317645 | — | — | 1 | 6.44 |
| CHEMBL99224 | — | — | 1 | 6.39 |
| CHEMBL98262 | — | — | 1 | 6.31 |
| CHEMBL433269 | — | — | 1 | 6.27 |
| CHEMBL318452 | — | — | 1 | 6.08 |
| CHEMBL101842 | — | — | 1 | 6.02 |
| CHEMBL295490 | — | — | 1 | 5.70 |
| CHEMBL73669 | — | — | 1 | 5.44 |
| CHEMBL317571 | — | — | 1 | 5.09 |
| CHEMBL1161504 | — | — | 1 | 4.89 |
| CHEMBL168147 | — | — | 1 | 4.58 |
| CHEMBL350207 | — | — | 1 | 4.51 |
| CHEMBL352694 | — | — | 1 | 4.34 |
| CHEMBL98838 | — | — | 1 | 4.29 |
| CHEMBL71078 | — | — | 1 | 4.17 |
| CHEMBL353063 | — | — | 1 | 4.12 |
| CHEMBL353758 | — | — | 1 | - |
| CHEMBL354279 | — | — | 1 | - |
| CHEMBL424387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317645 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL99224 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL98262 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL433269 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL318452 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL101842 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL295490 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL73669 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL317571 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1161504 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL168147 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL350207 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL352694 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL98838 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL71078 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL353063 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL353758 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL354279 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL424387 | — | IC50 | = | 180000.0 | nM | - |