Assay Detail
Functional
CHEMBL810941
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In vitro cytotoxic activity required to inhibit human bladder carcinoma T24 cell line
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.78 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423394 | — | — | 1 | 5.75 |
| CHEMBL148361 | — | — | 1 | 5.72 |
| CHEMBL145811 | — | — | 1 | 5.47 |
| CHEMBL356033 | — | — | 1 | 5.44 |
| CHEMBL358165 | — | — | 1 | 5.43 |
| CHEMBL150008 | — | — | 1 | 5.40 |
| CHEMBL146303 | — | — | 1 | 5.20 |
| CHEMBL149179 | — | — | 1 | 5.16 |
| CHEMBL435623 | — | — | 1 | 5.13 |
| CHEMBL423213 | — | — | 1 | 5.13 |
| CHEMBL357489 | — | — | 1 | 4.92 |
| CHEMBL149176 | — | — | 1 | 4.57 |
| CHEMBL148438 | — | — | 1 | 4.55 |
| CHEMBL146242 | — | — | 1 | 4.55 |
| CHEMBL344111 | — | — | 1 | 4.54 |
| CHEMBL358809 | — | — | 1 | 4.50 |
| CHEMBL148563 | — | — | 1 | 4.46 |
| CHEMBL146613 | — | — | 1 | 4.42 |
| CHEMBL149180 | — | — | 1 | 4.39 |
| CHEMBL356185 | — | — | 1 | 4.34 |
| CHEMBL149267 | — | — | 1 | 4.27 |
| CHEMBL434698 | — | — | 1 | 4.24 |
| CHEMBL150060 | — | — | 1 | 4.23 |
| CHEMBL146600 | — | — | 1 | 4.17 |
| CHEMBL149503 | — | — | 1 | 4.15 |
| CHEMBL146586 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423394 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL148361 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL145811 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL356033 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL358165 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL150008 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL146303 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL149179 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL435623 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL423213 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL357489 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL149176 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL148438 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL146242 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL344111 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL358809 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL148563 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL146613 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL149180 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL356185 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL149267 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL434698 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL150060 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL146600 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL149503 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL146586 | — | IC50 | = | 92000.0 | nM | 4.04 |