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Assay Detail

CHEMBL810946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration of compound required for acetylation of histone-4 in human T24 cancer cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type Cancer cell lines
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of a novel class of histone deacetylase inhibitors.
Lavoie R, Bouchain G, Frechette S, Woo SH, Abou-Khalil E, Leit S, Fournel M, Yan PT, Trachy-Bourget MC, Beaulieu C, Li Z, Besterman J, Delorme D.
Bioorg Med Chem Lett (2001) 11 : 2847 -2850
PubMed 11597413 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.33 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 6.00
CHEMBL98669 1 6.00
CHEMBL318642 1 5.82
CHEMBL97384 1 5.70
CHEMBL97272 1 5.30
CHEMBL317814 1 5.30
CHEMBL98346 1 5.30
CHEMBL98345 1 5.30
CHEMBL95553 1 5.30
CHEMBL95850 1 5.30
CHEMBL317570 1 5.00
CHEMBL96966 1 4.92
CHEMBL95680 1 4.70
CHEMBL95195 1 4.66
CHEMBL97860 1 -
CHEMBL95749 1 -
CHEMBL316457 1 -
CHEMBL100035 1 -
CHEMBL319248 1 -
CHEMBL97632 1 -
CHEMBL97387 1 -
CHEMBL95849 1 -
CHEMBL97108 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN EC50 = 1000.0 nM 6.00
CHEMBL98669 EC50 = 1000.0 nM 6.00
CHEMBL318642 EC50 = 1500.0 nM 5.82
CHEMBL97384 EC50 = 2000.0 nM 5.70
CHEMBL97272 EC50 = 5000.0 nM 5.30
CHEMBL317814 EC50 = 5000.0 nM 5.30
CHEMBL98346 EC50 = 5000.0 nM 5.30
CHEMBL98345 EC50 = 5000.0 nM 5.30
CHEMBL95553 EC50 = 5000.0 nM 5.30
CHEMBL95850 EC50 = 5000.0 nM 5.30
CHEMBL317570 EC50 = 10000.0 nM 5.00
CHEMBL96966 EC50 = 12000.0 nM 4.92
CHEMBL95680 EC50 = 20000.0 nM 4.70
CHEMBL95195 EC50 = 22000.0 nM 4.66
CHEMBL97860 EC50 > 25000.0 nM -
CHEMBL95749 EC50 > 25000.0 nM -
CHEMBL316457 EC50 > 25000.0 nM -
CHEMBL100035 EC50 > 25000.0 nM -
CHEMBL319248 EC50 > 25000.0 nM -
CHEMBL97632 EC50 > 25000.0 nM -
CHEMBL97387 EC50 > 25000.0 nM -
CHEMBL95849 EC50 > 25000.0 nM -
CHEMBL97108 EC50 > 25000.0 nM -