Assay Detail
Functional
CHEMBL811356
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Tested for cytotoxicity against antigen negative T-24 bladder carcinoma cells having only 3-5% antigen expression
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.00 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 2 | 5.39 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 2 | 5.39 |
| CHEMBL2368653 | — | — | 2 | 4.21 |
| CHEMBL2368656 | — | — | 2 | - |
| CHEMBL2368651 | — | — | 2 | - |
| CHEMBL1790204 | — | — | 2 | - |
| CHEMBL2368655 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2368653 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2368653 | — | IC50 | = | 21.0 | ug.mL-1 | - |
| CHEMBL2368656 | — | IC50 | = | 100.0 | ug.mL-1 | - |
| CHEMBL2368656 | — | IC50 | = | 263000.0 | nM | - |
| CHEMBL2368651 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL2368651 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 0.5 | ug.mL-1 | - |
| CHEMBL1790204 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL1790204 | — | IC50 | > | 280000.0 | nM | - |
| CHEMBL2368655 | — | IC50 | = | 79.0 | ug.mL-1 | - |
| CHEMBL2368655 | — | IC50 | = | 231000.0 | nM | - |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 1.0 | ug.mL-1 | - |