Assay Detail
Binding
CHEMBL811413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Bacterial Tyrosyl tRNA Synthetase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310012 | — | — | 1 | 9.22 |
| CHEMBL84867 | — | — | 1 | 8.47 |
| CHEMBL82579 | — | — | 1 | 6.91 |
| CHEMBL85201 | — | — | 1 | 6.61 |
| CHEMBL309467 | — | — | 1 | - |
| CHEMBL84569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310012 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL84867 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL82579 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL85201 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL309467 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL84569 | — | IC50 | > | 3000.0 | nM | - |