Assay Detail
Binding
CHEMBL811416
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Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.48 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51499 | — | — | 1 | 8.92 |
| CHEMBL1789974 | — | — | 1 | 8.85 |
| CHEMBL52779 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51499 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1789974 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL52779 | — | IC50 | = | 21.3 | nM | 7.67 |