Assay Detail
Binding
CHEMBL811473
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Compound was tested for inhibition of TEM-3, class A of beta-lactamases.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332565 | — | — | 1 | 7.27 |
| CHEMBL121924 | — | — | 1 | 7.04 |
| CHEMBL123481 | — | — | 1 | 6.85 |
| CHEMBL333330 | — | — | 1 | 6.80 |
| CHEMBL122209 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332565 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL121924 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL123481 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL333330 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL122209 | — | IC50 | = | 460.0 | nM | 6.34 |