Assay Detail
Binding
CHEMBL811592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibitory constant of human thymidylate synthase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Application of the three-dimensional structures of protein target molecules in structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9671 | — | — | 1 | 8.70 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 8.70 |
| CHEMBL275685 | — | — | 1 | 7.47 |
| CHEMBL9728 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9671 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL9440 | METESIND | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL275685 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL9728 | — | Ki | = | 1600.0 | nM | 5.80 |