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Assay Detail

CHEMBL811614

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of trypsin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL209)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.
Duncia JV, Santella JB, Higley CA, VanAtten MK, Weber PC, Alexander RS, Kettner CA, Pruitt JR, Liauw AY, Quan ML, Knabb RM, Wexler RR.
Bioorg Med Chem Lett (1998) 8 : 775 -780
PubMed 9871540 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.21 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2373367 1 8.85
CHEMBL2373350 1 8.72
CHEMBL2373397 1 8.68
CHEMBL2373402 1 8.64
CHEMBL2373440 1 8.57
CHEMBL2373348 1 8.38
CHEMBL2373475 1 8.32
CHEMBL2375178 1 8.25
CHEMBL2373559 1 8.18
CHEMBL2373400 1 8.15
CHEMBL2373405 1 8.08
CHEMBL2373346 1 8.02
CHEMBL2373408 1 7.92
CHEMBL2373403 1 7.64
CHEMBL2373351 1 7.46
CHEMBL2373345 1 7.44
CHEMBL2373302 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2373367 Ki = 1.4 nM 8.85
CHEMBL2373350 Ki = 1.9 nM 8.72
CHEMBL2373397 Ki = 2.1 nM 8.68
CHEMBL2373402 Ki = 2.3 nM 8.64
CHEMBL2373440 Ki = 2.7 nM 8.57
CHEMBL2373348 Ki = 4.2 nM 8.38
CHEMBL2373475 Ki = 4.8 nM 8.32
CHEMBL2375178 Ki = 5.6 nM 8.25
CHEMBL2373559 Ki = 6.6 nM 8.18
CHEMBL2373400 Ki = 7.1 nM 8.15
CHEMBL2373405 Ki = 8.4 nM 8.08
CHEMBL2373346 Ki = 9.6 nM 8.02
CHEMBL2373408 Ki = 12.0 nM 7.92
CHEMBL2373403 Ki = 23.0 nM 7.64
CHEMBL2373351 Ki = 35.0 nM 7.46
CHEMBL2373345 Ki = 36.0 nM 7.44
CHEMBL2373302 Ki > 1200.0 nM -