Assay Detail
Binding
CHEMBL811757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against mutant Plasmodium falciparum DHFR-TS
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL1939) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum K1 |
Publication
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.52 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278847 | — | — | 1 | 7.90 |
| CHEMBL29773 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278847 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL29773 | — | IC50 | = | 73.0 | nM | 7.14 |