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Assay Detail

CHEMBL811780

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of trypsin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL209)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biaryl substituted alkylboronate esters as thrombin inhibitors
Quan M, Wityak J, Dominguez C, Duncia J, Kettner C, Ellis C, Liauw A, Park J, Santella J, Knabb R, Thoolen M, Weber P, Wexler R
Bioorg Med Chem Lett (1997) 7 : 1595 -1600
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.46 10.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290376 1 10.35
CHEMBL418071 1 9.96
CHEMBL290212 1 9.21
CHEMBL287964 1 9.19
CHEMBL40854 1 9.15
CHEMBL41152 1 8.51
CHEMBL43140 1 8.42
CHEMBL289318 1 8.38
CHEMBL289147 1 8.33
CHEMBL263204 1 8.32
CHEMBL296663 1 8.28
CHEMBL290363 1 8.13
CHEMBL276881 1 7.89
CHEMBL297536 1 7.60
CHEMBL276880 1 7.48
CHEMBL290720 1 7.46
CHEMBL418427 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290376 Ki = 0.045 nM 10.35
CHEMBL418071 Ki = 0.11 nM 9.96
CHEMBL290212 Ki = 0.62 nM 9.21
CHEMBL287964 Ki = 0.64 nM 9.19
CHEMBL40854 Ki = 0.7 nM 9.15
CHEMBL41152 Ki = 3.1 nM 8.51
CHEMBL43140 Ki = 3.8 nM 8.42
CHEMBL289318 Ki = 4.2 nM 8.38
CHEMBL289147 Ki = 4.7 nM 8.33
CHEMBL263204 Ki = 4.8 nM 8.32
CHEMBL296663 Ki = 5.3 nM 8.28
CHEMBL290363 Ki = 7.4 nM 8.13
CHEMBL276881 Ki = 13.0 nM 7.89
CHEMBL297536 Ki = 25.0 nM 7.60
CHEMBL276880 Ki = 33.0 nM 7.48
CHEMBL290720 Ki = 35.0 nM 7.46
CHEMBL418427 Ki = 70.0 nM 7.16