Assay Detail
Binding
CHEMBL811867
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Compound was tested for inhibition of Tryptophan dioxygenase (TDO) from rat liver
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435072 | — | — | 1 | 7.52 |
| CHEMBL355606 | — | — | 1 | 7.52 |
| CHEMBL166509 | — | — | 1 | 7.52 |
| CHEMBL441669 | — | — | 1 | 7.40 |
| CHEMBL354352 | — | — | 1 | 7.40 |
| CHEMBL168956 | — | — | 1 | 7.30 |
| CHEMBL171548 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435072 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL355606 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL166509 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL441669 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL354352 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL168956 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL171548 | — | Ki | = | 100.0 | nM | 7.00 |