Assay Detail
Binding
CHEMBL811875
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The compound was evaluated for inhibition of trypanothione reductase enzyme
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Optimising inhibitors of trypanothione reductase using solid-phase chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.40 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76694 | — | — | 1 | 7.12 |
| CHEMBL79129 | KUKOAMINE A | — | 1 | 7.12 |
| CHEMBL307650 | — | — | 1 | 6.55 |
| CHEMBL76523 | — | — | 1 | 6.46 |
| CHEMBL76582 | — | — | 1 | 6.41 |
| CHEMBL78036 | — | — | 1 | 6.12 |
| CHEMBL308396 | — | — | 1 | 6.07 |
| CHEMBL77912 | — | — | 1 | 5.90 |
| CHEMBL76994 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76694 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL79129 | KUKOAMINE A | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL307650 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL76523 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL76582 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL78036 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL308396 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL77912 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL76994 | — | Ki | = | 1390.0 | nM | 5.86 |