Assay Detail
Binding
CHEMBL811883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human tumor necrosis factor alpha converting enzyme
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.40 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43087 | — | — | 1 | 9.28 |
| CHEMBL58577 | — | — | 1 | 8.77 |
| CHEMBL61193 | — | — | 1 | 8.64 |
| CHEMBL56837 | — | — | 1 | 8.21 |
| CHEMBL57644 | — | — | 1 | 7.82 |
| CHEMBL60536 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43087 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL58577 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL61193 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL56837 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL57644 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL60536 | — | Ki | = | 21.0 | nM | 7.68 |