Assay Detail
Binding
CHEMBL811896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.30 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109279 | — | — | 1 | 6.43 |
| CHEMBL112087 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109279 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL112087 | — | IC50 | = | 680.0 | nM | 6.17 |