Assay Detail
Binding
CHEMBL811900
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Inhibitory activity against [125I]T3 binding to human TRbeta1 receptor
25
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 9.31 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124126 | — | — | 1 | 10.70 |
| CHEMBL125381 | — | — | 1 | 10.52 |
| CHEMBL124205 | — | — | 2 | 10.40 |
| CHEMBL413699 | — | — | 1 | 10.15 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 10.10 |
| CHEMBL126693 | — | — | 1 | 10.00 |
| CHEMBL125728 | — | — | 1 | 9.89 |
| CHEMBL338602 | — | — | 3 | 9.80 |
| CHEMBL123920 | — | — | 1 | 9.64 |
| CHEMBL125946 | — | — | 1 | 9.55 |
| CHEMBL125317 | — | — | 1 | 9.51 |
| CHEMBL124039 | — | — | 1 | 9.40 |
| CHEMBL333650 | — | — | 1 | 9.34 |
| CHEMBL340158 | — | — | 1 | 9.34 |
| CHEMBL125242 | — | — | 1 | 9.20 |
| CHEMBL124318 | — | — | 1 | 9.19 |
| CHEMBL124819 | — | — | 1 | 9.14 |
| CHEMBL340490 | — | — | 1 | 8.72 |
| CHEMBL56801 | — | — | 1 | 8.70 |
| CHEMBL127338 | — | — | 1 | 7.89 |
| CHEMBL124145 | — | — | 1 | 7.57 |
| CHEMBL124844 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124126 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL125381 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL124205 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL124205 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL413699 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL1544 | LIOTHYRONINE | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL126693 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL125728 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL338602 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL123920 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL125946 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL125317 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL338602 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL124039 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL333650 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL340158 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL338602 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL125242 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL124318 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL124819 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL340490 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL56801 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL127338 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL124145 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL124844 | — | Ki | = | 10000.0 | nM | 5.00 |