Assay Detail
Binding
CHEMBL811904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositol
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Thyrotropin-releasing hormone receptor (CHEMBL2467) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.14 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | 9.31 |
| CHEMBL2370383 | — | — | 1 | 6.37 |
| CHEMBL107238 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | EC50 | = | 0.49 | nM | 9.31 |
| CHEMBL2370383 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL107238 | — | EC50 | = | 1800.0 | nM | 5.75 |