Assay Detail
Binding
CHEMBL811906
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Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Thyrotropin-releasing hormone receptor (CHEMBL2467) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Conformationally restricted TRH analogs: a probe for the pyroglutamate region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.56 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | 9.17 |
| CHEMBL36631 | — | — | 1 | 6.96 |
| CHEMBL607173 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL36631 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL607173 | — | EC50 | = | 290.0 | nM | 6.54 |